GSRS was developed through a collaboration between the FDA, NIH's National Center for Advancing Translational Sciences (NCATS), and international partners including EMA, USP, WHO, UMC, BfARM. The GSRS addresses the need for reliable substance tracking globally by defining substances by standardized, scientific descriptions focusing on ingredients and classifying them as chemical, protein, nucleic acid, polymer, structurally diverse, or mixture, following the guidelines of ISO 11238 and ISO DTS 19844. Importantly, GSRS is publicly accessible, providing a resource that can be utilized by researchers, regulators, and industry professionals, thereby encouraging wider use and integration into various regulatory and research efforts.